منابع مشابه
The minus end in sight
Microtubules are intrinsically polar structures. A consequence of this polarity is that the two ends of the microtubule polymer exhibit different properties. The more dynamic plus ends and the mechanisms that regulate their behavior have been the focus of much recent attention. Here, we concentrate on the dynamics and regulation of minus ends, which play distinct but equally critical roles in m...
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A minus end checkpoint B oth ends of microtubules get in on spindle checkpoint signaling. From kinetochores, proteins at microtubule plus ends relay the results of proper spindle-tochromosome attachments. Now, Hannah Müller, Bodo Lange (Max Planck Institute for Molecular Genetics, Berlin, Germany), and colleagues fi nd that, at minus ends, γ-tubulin signals that all is well with microtubule nuc...
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TIN filaments are required for cell locomotion and numerous intracellular activities in nonmuscle cells, and are a major component of the contractile apparatus in muscle cells. An understanding of the dynamics involved in the assembly and disassembly of actin filaments is fundamental to understanding many cellular functions. In this issue of The Journal of Cell Biology, Weber et al. (1994b) pro...
متن کاملMicrotubule Minus-End-Targeting Proteins
Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally and functionally distinct ends, the plus end and the minus end. Over the last decade, numerous studies have shown that microtubule plus-end dynamics play an important role in many vital cellular processes and are controlled by numerous factors, such as microtubule plus-end-tracking proteins (+TIPs). ...
متن کاملJuniors' hours: is the end in sight?
The question of how to reduce junior doctors' hours has taxed the government and hospital managers for nearly two decades. Now regional task forces are being asked to get them down to a maximum of 83 a week by 1 April next year. From a comparison of the way in which two different task forces (Northern and North West Thames) have responded to the challenge it emerges that most units will probabl...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(03)00530-x